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A prospective randomized study on the role of viscoadaptive OVD Healon5 versus combining viscodispersive-viscocohesive OVDs (soft-shell technique) in protecting the corneal endothelium during phacoemulsification of hard cataract

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Session Details

Session Title: Cat Surgery Equipment/inst/OVD

Session Date/Time: Tuesday 16/09/2014 | 16:30-18:00

Paper Time: 17:31

Venue: Boulevard B

First Author: : A.El-Sawy Habib -

Co Author(s): :    H. Makled              

Abstract Details


To evaluate the efficacy of the viscoadaptive OVD Healon5 in protecting the corneal endothelium during phacoemulsification of hard cataract as compared to using the dispersive-cohesive soft-shell technique in which the dispersive OVD Viscoat is combined with the cohesive OVD Provisc during surgery.




In this prospective randomized study, 30 eyes of 22 patients underwent phacoemulsification using either Healon5 (Group A, 15 eyes) or the dispersive-cohesive soft-shell technique (Group B, 15 eyes) with Viscoat and Provisc. All patients had age-related cataract, grades 3 and 4, with no other ocular pathology. Central corneal thickness (CCT) was examined preoperatively and at 1 and 7 days, as well as 1 month postoperatively. Corneal endothelial cell density (ECD) was examined preoperatively and 3 months postoperatively. The CCT and ECD were compared between the two groups.


There was no statistically significant difference in the mean preoperative and the mean postoperative central corneal thickness between the two groups during any of the follow up visits at 1 day, 7 days and 1 month postoperative. At 1 day postoperative, the mean increase in CCT in Group A was 64 ± 6μm while the mean increase in CCT in group B was 59 ± 8μm (P=0.076). At 7 days postoperative, the mean increase in CCT in Group A was 23 ± 7μm while in Group B it was 20 ± 8μm (P=0.302). After 1 month postoperative, the mean increase in CCT was 2 ± 4 and 3 ± 1 for Groups A and B respectively (P=0.452). Such differences in the mean increase in CCT between both groups were statistically insignificant in any of the follow up visits. Comparing endothelial cell loss after 3 postoperative months in the two groups, Group A had a 6.2 ± 0.4% cell loss while Group B showed 6.4 ± 0.3% cell loss. Such difference between the two groups was statistically insignificant (P=0.072).


The viscoadaptive agent Healon5 when utilized on its own is as effective as the dispersive cohesive soft-shell technique in protecting corneal endothelial cells during phacoemulsification of hard cataract.

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