Evaluation of corneal haze and depth of the demarcation line after accelerated and conventional cross-linking

Session Details

Session Title: Cross-Linking II

Session Date/Time: Tuesday 16/09/2014 | 16:30-18:00

Paper Time: 16:36

Venue: Boulevard A

First Author: : N.Kato JAPAN

Co Author(s): :    H. Takahashi   C. Sakai   M. Saiki   K. Negishi   K. Tsubota  

Abstract Details

Purpose:

To compare the intensity of the corneal haze and depth of the demarcation line after accelerated and conventional crosslinking (CXL).

Setting:

Department of Ophthalmology, Keio University School of Medicine

Methods:

Patients with recently progressing keratoconus who underwent CXL were analyzed retrospectively. In all cases, the preoperative thinnest corneal thickness exceeded 400 µm. After riboflavin presoaking for 20 minutes, accelerated CXL with ultraviolet-A irradiation (18 mW/cm2 for 5 minutes) was performed in ten eyes of ten cases (21.7 ± 7.4 years old; 8 males, 2 females) and conventional CXL (3.0 mW/cm2 for 30 minutes) was performed in 12 eyes of 11 patients (22.4 ± 4.0 years old; 4 males, 7 females). The corneal haze intensity was measured by densitometry with a Pentacam® (OCULUS, Germany) before and up to 6 months after the surgery. The depth of the demarcation line 1 month postoperatively was measured using FD-OCT Image (SS-1000, Tomey).

Results:

The intensity of the stromal haze evaluated using densitometry was 13.0 ± 1.2, 15.4 ± 1.5, 13.8 ± 0.9, and 12.1 ± 0.9 before and 1, 3, and 6 months, respectively, after accelerated CXL, and 14.0 ± 1.8, 20.8 ± 3.0, 18.8 ± 2.5, and 19.0 ± 2.6 after conventional CXL. The densitometry value was not increased significantly after accelerated CXL, but was increased after conventional CXL at all time points (all p<0.001). The depth of the demarcation line was 306.9 ± 13.9 µm after accelerated CXL and 300.6 ± 13.9 µm after conventional CXL (p=0.209).

Conclusions:

The postoperative stromal haze was significantly less intense after accelerated CXL, as compared to conventional CXL, although the depth of the demarcation line was equal, indicating that the crosslinking effect did not differ between the two procedures. Accelerated CXL might be as effective as conventional CXL and superior in terms of the formation of postoperative haze.

Financial Interest:

One or more of the authors... gains financially from product or procedure presented, One or more of the authors... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, One or more of the authors... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, One or more of the authors... is employed by a forNONEprofit company with an interest in the subject of the presentation