Neutrophil to lymphocyte ratio may predict progression in patients with keratoconus

Session Details

Session Title: Corneal Biomechanics

Session Date/Time: Monday 15/09/2014 | 17:00-18:30

Paper Time: 17:24

Venue: Capital Hall A

First Author: : E.Karaca TURKEY

Co Author(s): :    M. Özmen   F. Ekici   E. Yüksel        

Abstract Details

Purpose:

To evaluate neutrophil to lymphocyte ratio (NLR) of patients with keratoconus, and to analyze the possible difference between stable and progressive keratoconus and normal controls, with a view to contributing our understanding of whether NLR may predict the progression of disease.

Setting:

Gazi University Medical School, Department of Ophthalmology

Methods:

This cross-sectional observational study included 54 patients with keratoconus and 25 age and gender matched control subjects. Patients were separated into progressive and non-progressive keratoconus on the basis of topographic progression. All participants underwent a detailed ophthalmological examination and corneal topography. Serum samples were obtained from all subjects and NLR was calculated.

Results:

The NLR was 3.27 ± 1.37 in the progressive keratoconus group versus 1.87 ± 0.39 and 1.87 ± 0.52 in non-progressive and control groups, respectively (p<0.01). There was a positive correlation between NLR and progression (p<0.05). In the receiver operating characteristic analysis; a level of NLR ≥ 2.24 predicted the presence of progression with 79% sensitivity and 81% specificity.

Conclusions:

NLR is a simple and inexpensive marker of systemic inflammation. NLR increases in progressive keratoconus patients with compared to non-progressive group and controls.

Financial Interest:

NONE