Fluoride intake increases oxidative burden of cataractogenesis in flouride endemic areas in India

Session Details

Session Title: Special Cases

Session Date/Time: Sunday 14/09/2014 | 14:30-16:00

Paper Time: 15:48

Venue: Boulevard B

First Author: : S.Tomar INDIA

Co Author(s): :    A. Sharma   S. Tripathi           

Abstract Details

Purpose:

High fluoride exposure is associated with prevalence and severity of eye diseases. There are limited studies showing association of fluoride and cataractogenesis. Cataract is one of the major causes of a visual impairment, which eventually leads to blindness in India and worldwide, THUS THE STUDY WAS CONDUCTED TO CORRELATE THE OXIDATIVE STRESS IN POPULATION WITH HIGH CONTENT OF FLOURIDE IN DRINKING WATER WITH CATRACTOGENESIS

Setting:

Department of Ophthalmology, NIMS University, India

Methods:

Cross sectional study of 155 patients with cataract from the region where fluoride content was more than 2.5ppm in ground drinking water (Fluoride Endemic Area) was done. The control group with cataract was age and sex matched from the region where fluoride content was less than 1.5 ppm in their ground drinking water. Blood and crystalline lens were collected during cataract surgery for the assessment of oxidative stress marker namely; lipid peroxide levels (LPO), protein carbonylation (PC), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) content and fluoride and Vitamin A estimations were done in serum

Results:

We observed significant (p<0.001) increase of LPO and PC in study patients as compared to the control group in both serum and crystalline lens. On the other hand, antioxidant enzymes SOD and GSH were found to be markedly (p<0.01) decreased in study patients. Serum Fluoride was increased significantly (p<0.001) in patients residing in endemic area. Change in Vitamin A concentration was insignificant (p>0.05).

Conclusions:

We conclude that fluoride ingestion may directly influence the cataractogenesis by increased oxidative burden in people residing in fluoride endemic regions in rural India.

Financial Interest:

NONE