First steps towards a drug-eluting intraocular lens

Session Details

Session Title: IOL technology/New IOLs etc.

Session Date/Time: Saturday 13/09/2014 | 08:30-10:30

Paper Time: 08:42

Venue: Boulevard A

First Author: : A.Karamitsos GREECE

Co Author(s): :    L. Lamprogiannis   S. Logothetidis   V. Karagkiozaki   A. Laskarakis   S. Dimitrakos   I. Tsinopoulos

Abstract Details

Purpose:

The development, characterization and drug release study of single thin films based on organic polymers Poly-lactide-co-glycolide/Poly-capro-lactone (PLGA/PCL) and dexamethasone on the surface of Intraocular Lenses (IOL).

Setting:

1. 2nd University Eye Clinic , Aristotle University of Thessaloniki, Thessaloniki, Greece. 2. Laboratory for Thin Films, Nanosystems and Nanometrology, Department of Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Methods:

IOLs’ durability in spinning was tested using the spin coater. Two groups of IOLs (one-piece and three-piece) with thin film on their surface (blend PLGA:PCL 90:10 in ratio 3:1 with dexamethasone) were developed. The substrates (IOLs) and the thin films were studied using Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM) and Spectroscopic Ellipsometry (SE). Also, drug release studies were conducted for a 10 weeks period.

Results:

IOLs exhibited durability in higher spinning speeds than the ones used to develop thin films (650 rpm/sec for 6sec and then 2000 rpm for 30 sec). Thin films were developed on the optics and the haptics parts of the IOLs. Also, the thin films formed pores with aggregates of dexamethasone inside. The SE study showed transparent samples. The study of drug release demonstrated gradual drug release for the three-piece IOLs but not for the one-piece.

Conclusions:

The drug eluted three-piece IOLs that were developed using the spin coating method exhibit properties (transparency, drug release rate) and serve the purpose for intra-ocular drug delivery system.

Financial Interest:

NONE