Posters

Predictive factors of visual and topographic outcome of corneal collagen cross-linking (CXL)

Poster Details

First Author: W.Abou Samra EGYPT

Co Author(s):    A. Badawy   E. Azmy           

Abstract Details

Purpose:

To evaluate the effects of preoperative patient factors on clinical and topographic outcomes in patients treated with corneal cross-linking (CXL).

Setting:

Mansoura ophthalmic center

Methods:

This retrospective study included 113 eyes of 62 patients who were treated with conventional CXL for progressive keratoconus, pellucid marginal degeneration (PMD) and post LASIK ectasia. All patients underwent a complete ophthalmological examination and corneal topography at baseline and 1 year. Subgroup analyses were performed according to preoperative diagnosis, the age (< 25 and ≥ 25 years), gender, preoperative corrected distance visual acuity (CDVA < 0.3 and ≥ 0.3 logMAR), preoperative maximum keratometry (K < 56 and ≥ 56 D), baseline topographic cone location (central and paracentral), and preoperative thinnest pachymetry (< 450 and ≥ 450 um) to determine the associations between preoperative patient characteristics and outcomes of CXL treatment (changes in visual acuity, patients refraction and maximum keratometry).

Results:

In the entire study population, mean CDVA and maximum K significantly improved one year after CXL treatment (P < 0.01). Keratoconic patients showed more improvement in the CDVA and keratometry compared with patients with PMD or post refractive ectasia. Patients with a preoperative CDVA of 0.3 logMAR or worse experienced more visual improvement after CXL treatment. Patients with age 25 years or more and a baseline thinnest pachymetry less than 450 um were significantly associated with more flattening in maximum keratometry. More topographic flattening was demonstrated in eyes with centrally located cones compared with paracentral cone. Although patients with baseline maximum keratometry ≥ 54 D demonstrated more visual and topographic improvements, the results did not reach a significant level compared to patients with preoperative maximum keratometry < 54 D (P > 0.05).

Conclusions:

In patients treated with CXL, preoperative indication of CXL, age, baseline visual acuity, baseline thinnest pachymetry, and cone location seem to affect the outcome of the CXL treatment. On the other hand, gender and baseline keratometry are debatable factors for predicting the outcome of CXL. FINANCIAL INTEREST: NONE