Posters

Evaluation of corneal endothelium and keratic precipitates by confocal microscopy in Fuchs' uveitis syndrome

Poster Details

First Author: B.Basarir TURKEY

Co Author(s):    I. Cankaya   C. Altan   B. Satana   F. Ozcelik   A. Demirok  

Abstract Details

Purpose:

To evaluate keratic precipitates (KP) morphology and endothelial cell layer using in vivo confocal microscopy (IVCM) in patients with Fuchs' uveitis syndrome (FUS).

Setting:

Beyoglu Eye Training and Educational Hospital

Methods:

Thirty-three patients with unilateral FUS were evaluated with IVCM (Confoscan 4, Nidek, Italy). KP were classified as type I (small, round), type II (stippled), type III (dendritiform), and type IV (globular) in central 0.2 mm of corneal endothelium. Endothelial cell density (ECD) was measured both with IVCM and specular microscopy (SM). ECD measured with SM was compared with healthy eye of each patient. Endothelial cell morphology was also evaluated by IVCM.

Results:

The mean age of the patients was (36.0± 9 years). Type III (dendritiform) KP was the most frequently observed KP type (54.5%), followed by type I (small,round) KP (18.2%), type IV (globular) (15.2%), and type II (stippled) KP (12.1%). The mean endothelial cell density of eyes with FUS with IVCM was (2243,45 ± 381cells/mm2). The mean endothelial cell density of eyes with FUS with specular microscopy (2229,6 ± 119) was significantly lower than that of healthy eyes (2414,6 ± 70 cells/mm2) (t-test; p<0.001). Eyes with FUS which had dendritiform KP had a higher percentage of polymegathism (p=0.015)and a lower percentage of pleomorphism (p=0.025) compared with those with other type of KP. Endothelial blebs were observed in %75,8 of eyes with FUS.There was no significant correlation between the eyes with FUS with glaucoma and without glaucoma in terms of KP type, ECD and endothelial cell morphology.

Conclusions:

Dendritiform KP was the most frequently observed KP type in eyes with FUS. Eyes with dendritiform KP have higher percentage of polymegathism and lower percentage of pleomorphism. FUS is associated with decreased ECD. FINANCIAL INTEREST: NONE