Posters

Effects of topical cyclosporine 0.05% after cataract surgery in patients with dry eye

Poster Details

First Author: J.Lee SOUTH KOREA

Co Author(s):    Y. Park   M. Ahn           

Abstract Details

Purpose:

To evaluate the effectiveness of topically used cyclosporine 0.05% after cataract surgery, in mild to moderate dry eye patients.

Setting:

Prospective clinical trial

Methods:

Patient undergone unilateral cataract surgery without prior history of topical treatment was invited to participate in this study. Patients were classified in to three groups considering the severity of dry eye: Group 0 is the control group with no dry eye, Group 1 with level I dry eye, and Group 2 with level II dry eye. Patients received twice-daily treatment of cyclosporine 0.05% for 2 months after the cataract surgery. Disease severity was measured at 1 weeks, 1 month and 2 months by tear film break-up time (tBUT), Schirmer test I (ST-I), and dry eye symptom questionnaire (Ocular Surface Disease Index).

Results:

The study enrolled 66 patients of Group 0, 71 patients of Group 1, and 42 patients of Group 2. Group 0 showed significant improvement of tBUT at 2 months versus the initial examination. Group 1 and 2 showed significant improvement of initial tBUT at postoperative 1 month and further increase in 2 months. Group 1 showed significantly improved tBUT compared to Group 0 at 1 week. Group 2 showed significantly improved tBUT compared to Group 0 at 1 week, 1 month, and 2 months. Significant improvement of initial ST-I was found at postoperative 1 month in Group 0, and further increase in 2 months. Group 1 and 2 had significant improvement of initial ST-I only at postoperative 1 month. Dry eye symptom improved significantly at postoperative 2 months versus the initial examination in Group 0. Initial dry eye symptom improved significantly at postoperative 1 month and 2 months of Group 1. Significant improvement of initial dry eye symptom was found at 1 week in Group 2 and further improved until 2 months. Also, significant improvement of dry symptom in Group 2 compared to Group 0 was found at 1 week, 1 and 2 months.

Conclusions:

Topical cyclosporine 0.05% is more effective after cataract surgery in mild or moderate dry eye patients than normal patients, for the improvement in tBUT and dry eye symptom. FINANCIAL INTEREST: NONE