Posters

The possible effect of topical latanoprost on rabbit eye lashes: histological and ultra-structural study

Poster Details

First Author: N.Abdelhaliem EGYPT

Co Author(s):    A. Alsmman                    

Abstract Details

Purpose:

To study the clinical and histological changes by light microscope and electron microscope which may occur to rabbit eye lashes after topical use of latanoprost for two months

Setting:

sohag university

Methods:

Application of latanoprost (lumigan ) eye drops to the eye lid of 10 male rabbits daily for two months then scarification of rabbits and histological examination by light microscope and electron microscope with comparison to control untreated group.

Results:

This study confirmed clinical differences in hair appearance between the latanoprost-treated lashes and the untreated lashes, including increased number, length, thickness, curvature and pigmentation. Histological examination show increased number of hair follicles with hyperplasia of follicular cells and increased activity of the melanocytes in the form of irregular euchromatic nucleus and dilated rough endoplasmic reticulum.

Conclusions:

latanoprost has clinical and histological effect on hair follicles of eye lashes of male rabbits which may be harmful due to hyperplasia noted in both light and electron microscope.

Financial Disclosure:

None