Posters

Comparative analysis of outcomes of customised topography-guided cross-linking vs conventional cross-linking for keratoconus

Poster Details

First Author: S.Ramamurthy INDIA

Co Author(s):    G. Sachdev                    

Abstract Details

Purpose:

The purpose of the study was to compare the outcomes of Customised topography guided versus conventional cross linking in the management of Progressive Keratoconus

Setting:

Cornea Services, The Eye Foundation, Coimbatore, India.

Methods:

Prospective interventional study conducted between June 2016 to August 2017. Consecutive patients with documented progression of Keratoconus and a minimal thickness of 400u were included in the study. All patients underwent cross linking using the epithelium off approach. An accelerated 9mw/cm2 for 10 mins protocol was used in the conventional group(Group A). In the customized group (Group B), 3 concentric zones receiving 15, 10 & 5.4J/cm2 of energy centered around the highest point on the posterior float using a pulsed 30mW/cm2 beam. Outcome parameters included extent of flattening, improvement in visual acuity & depth of demarcation line.

Results:

60 eyes (30 in each group) were included in the study. At 6 months follow up a mean maximal flattening of 2.9D was achieved in Group B as compared to 1.1D in Group A (p=0.02). The I-S index, ratio of inferior to superior flattening, was also better in Group B (p = 0.032). Mean depth of demarcation line was 181u in Group A and 254u in Group B(p=0.04). Greater proportion of eyes had improvement in UDVA in Group B(62%) as compared to 18% in Group A. Extent of haze and specular counts were comparable between both groups at 3 months.

Conclusions:

Customised topography guided cross linking provided superior flattening and greater improvement in visual acuity as compared to conventional crosslinking while maintaining the same degree of safety.

Financial Disclosure:

None