Posters

Effectiveness of platelet-rich plasma and 0.01% sulfated glycosaminoglycans for treatment of chronic corneal erosions, associated with herpetic keratitis

Poster Details

First Author: A.Loshkareva RUSSIA

Co Author(s):    D. Maychuk                    

Abstract Details

Purpose:

To estimate effectiveness of platelet-rich plasma (PRP), isolated or in combination with 0,01% sulfated glycosaminoglycans, for treatment of herpetic recurrent cornea erosion syndrome with previously unsuccessful courses of reparative treatment.

Setting:

Therapeutic Ophthalmology Department. Svyatoslav Fyodorov State Institution Eye Microsurgery Complex, 59A Beskudnikovskii Blvd, 127486, Moscow, Russia.

Methods:

2 groups of patients (60 eyes) with recurrent corneal erosion syndrome and one-side Herpetic keratitis in anamnesis, age 48,4±9,7 were included. At first step all had antiviral therapy (Gancyclovir 0,15%, Valcyclovir 500mg.). At 2-nd step patients were divided in 2 groups and vein blood with Sodium citrate and Dextrosa subjected to double centrifugation, 4 min. at 3500 rpm, was used. 1-st group was receiving PRP instillations 6 times daily. 2-nd group - PRP in the combination with 0,01% sulfated glycosaminoglycans. Additional therapy included Dexpanthenol 5%. Dynamic of treatment was assessed by Efron scale. Condition before treatment was used for control.

Results:

Index of the corneal lesion before treatment was 7,1±1,9 at the 1-st and 6,9±1,8 points at the 2-nd group. After 8 weeks of treatment is was 2,1±2,1 and 1,9±2,2 points in groups. Full corneal epithelialization was observed at 14 patients in the 1-st group, at 15 patients in 2-nd group. All other patients in groups had positive dynamic and corneal lesion depression, but had no full epithelialization. An equivalent improvement in both groups was noted.

Conclusions:

Comparative analysis with standard methods of therapy featured positive dynamic in groups with PRP treatment.

Financial Disclosure:

None