Can hydrophobic tinted acrylic IOL prepared by cast molding endure accelerated stress test?

Session Details

Session Title: Presented Poster Session: IOL Opacification

Venue: Poster Village: Pod 1

First Author: : K.Kawai JAPAN

Co Author(s): :                           

Abstract Details

Purpose:

Recently developed intraocular lenses (IOL) prepared by cast molding, Acrysof® (SN60WF) and Vivinex® (XY1), were subjected to an accelerated stress degradation experiment to predict their conditions after 20 years.

Setting:

Tokai University School of Medicine

Methods:

Tinted acrylic hydrophobic IOL prepared by cast molding, SN60WF (45 lenses), and XY1 (10 lenses), were tested. IOL were immersed in 9-mL screw tube bottles containing ultra-pure water and kept standing at 100°C for 115 days. Deterioration of IOL with time was judged based on changes in the external appearance, weight change rate, light transmittance, and phenylethyl alcohol leaked into preservative solution measured using a gas chromatography-mass spectrometer (GC-MS).

Results:

SN60WF: On external observation, changes suggesting deterioration were noted in 24% (11 lenses). The mean weight change rate was -1.23%, showing a significant reduction. The light transmittance decreased by about 7% in 10 of the 11 deteriorated lenses and about 36% in one lens. Phenylethyl alcohol was detected in 12 of 14 lenses on GC-MS. XY1: No change in the external appearance was noted. The mean weight change rate was -0.24%, showing a significant reduction. The light transmittance of the lens increased within a range of 400-500 nm after the test. Phenylethyl alcohol was detected in all lenses on GC-MS.

Conclusions:

It was suggested that SN60WF and XY1 prepared by cast molding easily deteriorate. Moreover, SN60WF may be more markedly deteriorated than XY1 with regard to the external appearance, weight change rate, and light transmittance.

Financial Disclosure:

receives non-monetary benefits from a company producing, developing or supplying the product or procedure presented.