Subclinical keratoconus and forme fruste keratoconus: a systematic review of the existent literature about definitions and discriminative criteria

Session Details

Session Title: Presented Poster Session: Training & Quality of Vision

Venue: Poster Village: Pod 3

First Author: : M.Henriquez PERU

Co Author(s): :    L. Izquierdo Jr   M. Hadid   C. Maldonado   J. Chauca              

Abstract Details

Purpose:

To identify and analyzed keratoconus terminology and discriminative criteria used in studies of subclinical keratoconus (SCK) and/or forme fruste keratoconus (FFKC).

Setting:

Instituto Oftalmosalud - Research Department

Methods:

: Prospective, systematic review of electronic database in PubMed, the Cochrane Library, Embase and the Chinese Biomedicine Database of all studies using the keywords “subclinical keratoconus and/or forme fruste keratoconus.” Two independent reviewers analyze the data; the Quality Index assessed the quality of the included literature. We analyzed the selected articles in the following aspects: type of the study, sample size, diagnosis criteria for SCK and FFKC, suggested discriminative parameters, cutoff values, and technology used. Statistical analysis was performed using Stata 13 software.

Results:

The initial search yielded 198 articles, from them 103 where included. From SCK studies, 4.85% were cases series, 40.77% were retrospective study, 38.83% prospective study, 21.35 % cross-sectional study. 43.68% explain the subclinical keratoconus definition used and 53.39% only refers to a reference cited the article. 82.52 % refers to a more than one variable to discriminate between normal and SCK. 29.12% included elevation data, 30.09% aberrometric data, 5.82% biomechanical data, 82.52 curvature data to distinguish between normal and SCK. The discriminative analysis reported a sensitivity and specificity range between 60-99% and 63-99% to distinguish between normal and SCK respectively.

Conclusions:

Subclinical keratoconus refers to a cornea with one or more tomographic and/or topographic signs of keratoconus and normal-appearing cornea at slit-lamp biomicroscopy. More than 90% of the studies refer to a more than 1 parameter to discriminate between normal and subclinical keratoconus eyes rather than a single parameter.

Financial Disclosure:

None