Effect of oral digoxin use on corneal endothelium

Session Details

Session Title: Cornea Miscellaneous

Session Date/Time: Monday 24/09/2018 | 16:30-18:00

Paper Time: 17:36

Venue: Room A3, Podium 3

First Author: : A.Ataç TURKEY

Co Author(s): :    S. Sul                    

Abstract Details

Purpose:

To determine the effect of digoxin which is a Na-K ATPase blocker on corneal morphological parameters

Setting:

Department of ophthalmology, Muğla Sıtkı Koçman University Faculty of Medicine

Methods:

46 eyes of 46 women were enrolled in this study. Group 1 consisted of 18 women who received oral digoxin due to heart failure at least 1 year. Blood digoxin levels were between normal therapeutic range (0.5-2ng/mL). Group 2 consisted of 28 aged and sex match healthy women. Patients with history of intraocular surgery and trauma, corneal dystrophy, pseudoexfoliation and diabetes were excluded. Corneal endothelial cell density (CD,cells/mm2), cell area (µm2), Polymegethism (CV) and pleomorphism (Hexagonality) were evaluated with non-contact specular microscopy and compared between two groups. Central corneal thickness (CCT) was evaluated with ultrasonic pachymeter.

Results:

Mean age was 75.3±4 in group 1 and 75.4±3 in group 2 (p=0.940). Mean CD was 2527±152/mm2 in group 1 and 2555±204/mm2 in group 2 (p=0.613). Mean cell area was 390±29 µm2 in group 1 and 399±40 µm2 in group 2 (p=0.451). CV (31±2% in group 1 and 30±5 % in group 2 respectively, p=0.612) and hexagonality (68.3±3% in group 1 and 69.6±3% in group 2 respecively, p=0.159) were similar between two groups. Mean CCT was 548±24 µ in group 1 and 546±26µ in group 2 (p=0.892).

Conclusions:

Digoxin use within the normal blood therapeutic levels seem to have no deleterious effect on corneal endothelial cell morphology.

Financial Disclosure:

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