The effect of glycemic control on aqueous humour glucose levels in diabetic patients undergoing elective cataract surgery

Session Details

Session Title: Corneal Endothelium & Cataract Surgery

Session Date/Time: Monday 24/09/2018 | 16:30-18:00

Paper Time: 17:45

Venue: Room A3, Podium 1

First Author: : I.Barequet ISRAEL

Co Author(s): :    N. Gomel   N. Bourla   A. Einan-Lifshitz   L. Lipsky           

Abstract Details

Purpose:

The glucose levels in the aqueous humour may affect the pathophysiology of cataract and other anterior segment diseases. We evaluated the correlation between of aqueous and plasma glucose levels, and HbA1c (as a measure glycemic control) in diabetic patients undergoing cataract surgery.

Setting:

Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel

Methods:

This prospective study was performed in patients previously diagnosed with diabetes admitted for elective cataract surgery. Plasma glucose levels were evaluated immediately prior to the operation and HbA1c was obtained within 3 months preoperatively. At the beginning of the operation aqueous humour was drawn for glucose level measurement. The main outcome was the correlation between HbA1c and aqueous humou (AHG)-plasma (PG)glucose correlation. The effect of age, plasma glucose levels and duration of disease on this correlation was evaluated.

Results:

In the 37 patients recruited average AHG-PG was 0.69(±0.20) and Pearson coefficient constant R=0.63 (P<0.05). A significantly strong positive correlation was found between HbA1c and AHG-PG R=0.62 (P<0.05). Among male patients (n=16) a significantly strong positive correlation was found between HbA1c and AHG-PG R=0.70 (P<0.05). Amidst female patients (n=21) AHG-PG was found with significant strong positive correlation R=0.74 (P<0.05) and the correlation AHG-HbA1c was significantly strong R=0.67 (P<0.05). Among older patients (>80y, n=12) a very strong significant positive AHG-PG correlation was found R=0.89 (P<0.05) and a very strong significant correlation between AHG -HbA1c R=0.82 (P<0.05).

Conclusions:

A significantly strong AHG-PG correlation was found in the study, especially in in older age and female gender. We concluded that poor glycemic control is correlated to an increased anterior chamber’s glucose permeability as HbA1c level was found significantly strongly effecting AHG-PG correlation. An increased effect was found in male patients and older patients. Those findings may have an important application to diabetic cataract and diabetic eye diseases.

Financial Disclosure:

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