Intraocular pressure elevation after cataract surgery and its prevention by oral acetazolamide in eyes with pseudoexfoliation syndrome

Session Details

Session Title: Cataract Surgery & Glaucoma

Session Date/Time: Sunday 23/09/2018 | 14:00-16:00

Paper Time: 15:04

Venue: Room A3, Podium 1

First Author: : K.Hayashi JAPAN

Co Author(s): :    M. Yoshida   T. Sato   S. Manabe   K. Yoshimura           

Abstract Details

Purpose:

To examine whether intraocular pressure (IOP) increases immediately after cataract surgery in eyes with pseudoexfoliation syndrome, and to assess whether orally administered acetazolamide can prevent the IOP elevation.

Setting:

Hayashi Eye Hospital, Fukuoka, Japan.

Methods:

One hundred two eyes of 102 patients with pseudoexfoliation scheduled for phacoemulsification were randomly assigned to one of three groups: 1) oral acetazolamide administered 1 hour preoperatively (preoperative administration group), 2) administered 3 hours postoperatively (postoperative administration group), and 3) not administered (no administration group). IOP was measured using a rebound tonometer at 1 hour preoperatively, upon completion of surgery, and at 1, 3, 5, 7, and 24 hours postoperatively.

Results:

Mean IOP was increased at 3, 5, and 7 hours postoperatively in all groups. At 1 and 3 hours postoperatively, the IOP was significantly lower in the preoperative administration group than in the postoperative and no administration groups (P≤.0004). At 5, 7, and 24 hours postoperatively, the IOP was significantly lower in the preoperative and postoperative administration groups than in the no administration group (P≤.0045). An IOP spike to higher than 25 mmHg occurred less frequently in the preoperative administration group than in the postoperative and no administration groups (P=.0337).

Conclusions:

IOP was increased at 3, 5, and 7 hours after cataract surgery in eyes with pseudoexfoliation. Oral acetazolamide administered at 1 hour preoperatively reduced the IOP elevation throughout the 24-hours follow-up, while acetazolamide administered at 3 hours postoperatively reduced the elevation at 5 hours postoperatively and thereafter.

Financial Disclosure:

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