Phototherapeutic intrastromal corneal collagen cross-linking (PiXL) for treatment of low-grade myopia: comparison of different UV irradiation protocols

Session Details

Session Title: Surgical Cornea

Session Date/Time: Tuesday 25/09/2018 | 16:30-18:00

Paper Time: 17:24

Venue: Room A3, Podium 3

First Author: : A.Behndig SWEDEN

Co Author(s): :    A. Fredriksson   S. Naslund                 

Abstract Details

Purpose:

To compare the efficacy and safety of PiXL for low-grade myopia with UV irradiation in a central 4-mm zone and in central 3.5 - 4 mm ring-shaped zones.

Setting:

Department of Clinical Sciences/Ophthalmology, Umeå University, Umeå, Sweden.

Methods:

Low-grade myopic participants were treated with high-oxygen epi-on PiXL, comparing different UV irradiation protocols. Corrected (CDVA) and uncorrected visual acuities (UDVA), refractive spherical equivalents (SE), endothelial cell count (ECC) and adverse events were analyzed pre- and postoperatively.

Results:

In the 4-mm protocol, UDVA improved from 0.62±0.25 to 0.11±0.21 LogMAR and the SE from -1.43±0.53D to -0.39±0.46D (p<0.001) at 6 months. A 4-mm ring zone displayed similar results. We also present early results with a modified 3.5-mm ring protocol. The ECC and CDVA remained unchanged. No adverse events occurred.

Conclusions:

Our results indicate that these PiXL protocols are promising non-invasive alternatives to refractive surgery for low-grade myopic patients, with an effect exceeding 1D in SE. The results of this ongoing study are preliminary, and longer follow-up is needed to evaluate the stability of the results.

Financial Disclosure:

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