10 year results of conventional corneal cross-linking in progressive keratoconus

Session Details

Session Title: Cross-Linking

Session Date/Time: Tuesday 25/09/2018 | 14:00-16:00

Paper Time: 14:40

Venue: Room A3, Podium 3

First Author: : E.Usubov RUSSIA

Co Author(s): :    M. Bikbov   G. Bikbova   V. Surkova   M. Astrelin           

Abstract Details

Purpose:

To study the long-term (10-years) clinical outcomes of the conventional corneal crosslinking of in progressive keratoconus

Setting:

Ufa Eye Research Institute A retrospective analysis of the results of treatment of 19 patients (24 eyes) with progressive keratoconus I-II stages according to the Amsler-Krumeich classification, which were treated by standard corneal crosslinking.

Methods:

The average age of the patients is 22±2.9 years. Patient selection criteria: initial thickness after de-epithelialization of at least 400 μm, saturation of the cornea with a photosensitizer for 25 minutes, UV-A irradiation (UV-A) of the cornea for 30 minutes at a radiation power of 3 mW/cm2 and a wavelength of 370 nm. Preop, NCVA was 0.17±0.08, BCVA was 0.59±0.24, the average keratomerty (Kave) was 50.99±0.29 D, the corneal astigmatism (CA) value was 4.6±0.34D, the corneal thickness (CT) - 465±85 mc

Results:

At 3 months the UCVA and BCVA decreased to 0.11±0.08 and 0.45±0.58, respectively. The CT increased to 479±103 μm. In 1 year UCVA - 0.25±0.1, BCVA - 0.6±0.12. Kave decreased by 1.7±0.14 D, the CT by 438±72 μm. Stabilization occurred during the 3 years. After - no statistically significant changes in clinical and functional indicators. During the 10-year observation period the process stabilized in 87.5% with a decrease of Kave by 2.05±1.25D, CA by1.3±0.31D, CT to 415±29 mc.In 3 cases, Kave increased by 1.0D after 6 years, and by 1.5D after 8 years.

Conclusions:

10-year observations showed high efficiency of the conventional corneal crosslinking protocol in progressive keratoconus, which provides stabilization of the disease in 88% of cases. This method affects the pathogenetic links of the disease and allows not only to avoid progression, but also to improve anatomical and functional results

Financial Disclosure:

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