Average lens density quantification with swept-source OCT integrated into the IOLMaster 700: an optimised and automatised version of the technique for cataract grading

Session Details

Session Title: Biometry & Quality of Vision

Session Date/Time: Tuesday 25/09/2018 | 08:00-10:30

Paper Time: 08:18

Venue: Room A2

First Author: : C.Panthier FRANCE

Co Author(s): :    A. De Wazieres   H. Rouger   A. Saad   D. Gatinel           

Abstract Details

Purpose:

To assess the upgrade of our new objective cataract grading method based on lens densitometry on Swept-Source Optical Coherence Tomography (SS-OCT) scans provided by the IOLMaster 700.

Setting:

Single centre study at the Rothschild Foundation, Paris, France

Methods:

All patients consulting for cataract evaluation who provided their consent to participate in the study were included. History of eye surgery, cornea or retina disorders, and ocular dryness were exclusion criteria. The average lens densitometry (ALD) was measured on SS-OCT scans provided by the IOLMaster 700 using our algorithm developed on MATLAB® software. The ocular scatter index (OSI) measured with a double-pass aberrometer (OQAS®), the “Pentacam Nucleus Staging” (PNS) score and mean PNS were also measured and compared to the ALD.

Results:

285 eyes (195 with cataract and 90 controls) of 155 patients aged 20-93 years (mean ± SD: 56.5 ± 21 years) were included. ALD measurements were repeatable (P=0.99, ANOVA). The ALD correlated with the OSI (r² = 0.41, P <0.01), PNS score (r² = 0.65, P <0.01). An ALD greater than 73.8 pu was the cut-off threshold for cataract with 96.2% of sensitivity and 91.3% of specificity. Discriminant analysis produced a model combining visual acuity and mean ALD with an area under the ROC curve (AUROC) of 0.975 (p<0.001) where mean ALD had the highest coefficient.

Conclusions:

ALD measured by our upgraded automatized algorithm based on SS-OCT is a repeatable and reliable objective cataract grading method.. In case of ALD greater than 73.8 pu, cataract surgery may be discussed if patient had visual impairment.

Financial Disclosure:

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