Trehalose/sodium hyaluronate/carbomer eye drops in post-cataract ocular surface disorders

Session Details

Session Title: Corneal Endothelium & Cataract Surgery

Session Date/Time: Monday 24/09/2018 | 16:30-18:00

Paper Time: 16:30

Venue: Room A3, Podium 1

First Author: : C.Cagini ITALY

Co Author(s): :    A. Beccasio   T. Fiore   G. Torroni   G. Di Lascio           

Abstract Details

Purpose:

To evaluate the efficacy of trehalose/sodium hyaluronate/carbomer eye drops ( THEALOZ ® gel / THEALOZ DUO ® gel ) for ocular discomfort and tear-film stability in patients undergoing cataract surgery

Setting:

Department of Biomedical and Surgical Sciences, Ophthalmology Section, University of Perugia, S. Maria della Misericordia Hospital, Piazza Menghini 1, S. Andrea delle Fratte, 06156 Perugia, Italy

Methods:

Patients scheduled for cataract surgery were included and randomized to receive trehalose/sodium hyaluronate/carbomer eye drops fix combination (group 1) or 0.9% unpreserved sodium chloride eye drops (group 2) , in addition to our post surgery standard protocol (topical antibiotic/corticosteroid and topical NSAIDs). Outcome measures were tear breakup time (TBUT), Schirmer test , ocular surface disease index (OSDI), dry-eye symptoms evaluated using a visual analog scale (VAS), corneal fluorescein staining (Oxford score) and patients satisfaction assessed with a visual analog scale (VAS). Patients were assessed immediately before surgery, 2 and 4 weeks after surgery. T-test was used for statistical analysis

Results:

40 patients completed the study. In group 1 (trehalose/sodium hyaluronate/carbomer eye drops) all outcome parameters significantly improved 4 weeks after surgery vs preoperative assessment (p<0,05 ), while no significant change occurred in group 2 , except an slight improvement of OSDI score. Therefore a statistically significant difference between the groups was observed for all outcome parameters except Schirmer test. Patients’ satisfaction resulted significantly higher in group 1 vs group 2 ( 9,6 vs 5,7 respectively; p<0,001). No adverse events were reported

Conclusions:

Trehalose/sodium hyaluronate/carbomer eye drops were effective and well tolerated in relieving signs and symptoms of post cataract ocular surface discomfort and tear film stability

Financial Disclosure:

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