Three year graft survival: a comparison of survival of DALK, DSAEK, DMEK, and PK

Session Details

Session Title: Surgical Cornea: Keratoplasty & Corneal Grafts

Session Date/Time: Sunday 23/09/2018 | 14:00-16:00

Paper Time: 14:18

Venue: Room A3, Podium 3

First Author: : E.Infantes Molina SPAIN

Co Author(s): :    J. Celis Sanchez   E. Avendao Cantos   D. Mesa Varona   J. Galváz Marte­nez   M. Pradas González   F. González del Valle     

Abstract Details

Purpose:

To compare 3-year graft survival after Deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK), Descemet´s membrane endothelial keratoplasty (DMEK) and penetrating keratoplasty (PK).

Setting:

La Mancha Centro Hospital, Alcázar de San Juan, Ciudad Real. Spain

Methods:

Consecutive patients who underwent DALK (55 eyes), DSAEK (69 eyes), DMEK (60 eyes) or PK (86 eyes) for several cornea pathologies. Clinical data and characteristics of the donor and recipient were recorded from our prospective cohort of the Corneal Transplant Registry. All surgeries were performed by the same corneal surgeon. We include cases made during the learning curve.

Results:

Overall mean age was 60.8 years, and 38.7% of patients were men. The median survival of the transplants during the follow-up period was 36 months (95% CI, 33.6 - 39.6 months). Overall 3-year graft survival was superior for DALK, followed by PK, DSAEK, and finally DMEK (P<0.001, log-rank test). Three-year cumulative incidence of complications such as graft rejection (P<0.001), epitheliopathy (P<0.001), suture-related corneal infections (P<0.001), and wound dehiscence (P=0.002) were greater in the PK group compared with the other groups. The primary failure was frequent in DMEK.

Conclusions:

3-year graft survival was superior for DALK compared with PK. The DMEK technique had the most unfavorable survival rate, mainly in the first two years.

Financial Disclosure:

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