Posters

Efficacy of topical steroid vs oral steroid in the treatment of acute ocular chemical burns

Poster Details

First Author: M.Henriquez PERU

Co Author(s):    M. Camino   R. Zúñiga   C. Maldonado   N. Canorio   J. Chauca   L. Izquierdo Jr     

Abstract Details

Purpose:

To compare the efficacy of the topical corticosteroid and a combination using topical and oral corticosteroid in acute ocular chemical burns.

Setting:

Instituto de Ojos Oftalmosalud, Lima, Perú

Methods:

Experimental, randomized controlled trial where 15 eyes from 15 rats had standardized severe corneal alkali-burn in the right eye with 0.5N NaOH. Rats were randomly divided according to the treatment to be received: control (no treatment), topical and combined treatment. Topical group had 1ug of prednisolone acetate each 4hour and combined group had same topical treatment plus oral Prednisone (0.5ml/cc per day). Evaluation at days 1,3,6 and 10 was performed for corneal opacity, re-epithelization status. At day 10th impression cytology and histopathology of the corneal tissue was assessed. Statistical analysis was performed using the R program and Kruskal Wallis test.

Results:

All 15 eyes rats had alkali ocular burns grade IV according to Roper-Hall Classification System. Mean number of trunks per quadrant were 7.5±3.42; 5.00±2.16 and 4.25±1.5 in control group, topical and combined treatment, respectively (p=0.03). Mean number of neo-vassels per quadrant were 54.25±24.34; 8.25±4.27 and 5.25±2.06 in control group, topical and combined treatment, respectively (p=0.007). Mean inflammatory cells was in topical and combined treatment was 1262±822.26 and 728±396.79 respectively (p=0.48).

Conclusions:

Combined treatment using topic and oral corticosteroids is better than topical corticosteroids alone in preventing corneal neovascularization and in reducing inflammation after acute chemical ocular burns in a rats model.

Financial Disclosure:

None