Posters

Correction of metabolic disorders in the prevention and treatment of diabetic retinopathy

Poster Details

First Author: S.Mykhalchyk UKRAINE

Co Author(s):    N. Zavgorodnyaya                    

Abstract Details

Purpose:

Lack of knowledge for individual links in pathogenesis and their interaction does not allow to fully create a harmonious system of treatment, as well as the prevention of diabetic retinopathy. In the study of the pathogenesis of diabetic retinopathy, the activation of lipid peroxidation and reduction of the activity of the AOS system (catalase, HPA, superoxide dismutase) in the blood, also increased the level of proangiogenic vascular endothelial growth factor, and decreased the activity of the factor derived from the pigmentary epithelium of blood vessels (PEDF) in the system of eye metabolism and attenuation of antioxidant defence in these patients.

Setting:

Zaporozhye State Medical University, Ukraine

Methods:

The research is based on an analysis of the results of the state of the antioxidant system in the blood of patients with DR of varying degrees of severity before and after treatment with the use of an antioxidant drug. The results of clinical and biochemical studies performed in 178 patients, 356 eyes All patients received the necessary hypoglycemic drugs. Ophthalmic examination included: visus, perimetry, tonometry, ophthalmoscopy, fluorescein angiography (FAG), biomicroscopy. Ophthalmic examination included computer perimetry, phospho-test ), optical coherence tomography with n ZEISS Cirrus HD -OCT 4000 (3D image).

Results:

The relationship between oxidative stress activation, NO dysfunction and the factors regulating angiogenesis in the formation of diabetic retinopathy is first shown. It was first established that under the action of AOS of short-chain carotenoids, the expression of key molecular regulators of PEDF and vascular endothelial growth factor (VEGF) -regulations, as well as indicators of the NO-expression of iNOS expression and the maintenance of a stable metabolite NO-was normalised. It has been established that this effect of the drug is associated with inhibition of oxidative stress reactions against the background of increased activity of antioxidant enzymes.

Conclusions:

On the basis of detected AFO-dependent mechanisms of the formation of diabetic retinopathy, the expediency of incorporating short-chain carotenoids into the complex therapy of diabetic retinopathy has been substantiated and proved to correct the expression of molecular factors of angiogenesis, nitroxidergic system, and visual functions. It was found out that it is expedient for laboratory diagnostics of diabetic retinopathy and control of the effectiveness of its treatment to determine in the blood of patients with diabetes markers of oxidative stress - AFO and KFK, nitroxyergic system - iNOS, angiogenesis - VEGF for predicting the further development of DR.

Financial Disclosure:

None