Posters

Ocular surface disorder among adult type-II diabetes mellitus patients and its correlation with tear film markers: a cross-sectional comparative study

Poster Details

First Author: V.Kumari INDIA

Co Author(s):    N. Kasturi   M. Rajappa   D. Gochhait              

Abstract Details

Purpose:

To study the ocular surface changes among diabetes mellitus patients and to correlate them with tear film markers like Tumour Necrosis Factor-alpha(TNF alpha), Interleukin-1beta (IL-1Beta), and Insulin like Growth Factor- 1 (IGF-1).

Setting:

Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER, Puducherry)- A tertiary care hospital in South India.

Methods:

The study was carried out on diabetic patients (>5 years duration) and healthy age and gender-matched controls with 21 subjects in each group. Ocular surface disease index (OSDI) for symptomatic assessment of dryness, Schirmer’s test for basal and reflex tear secretion, tear film breakup time (TBUT) for tear stability, ocular staining score (OSS)for dryness severityand conjunctival impression cytology (IC)for epithelial cell integrity, keratinization, squamous metaplasia, goblet cell density was studied.Thirty microliters of tears were collected to test IGF- 1, IL-1b and TNF-a levels.

Results:

Diabetes mellitus (DM) patients showed significantly low Schirmer’s, TBUT and OSS values than controls. OSDI score showed moderate-severe dryness in DM patients and only mild symptoms among controls. Abnormal IC score was seen among cases and controls. The level of TNF- a was significantly increased in DM patients and positively correlated with OSDI, Schirmer, and TBUT values among cases (P<0.05).

Conclusions:

Dry eye is more prevalent in DM patients compared to controls as evident by poor OSDI score, Schirmer, TBUT and OSS. TNF- a  in the tears of DM patients is a useful marker which showed good correlation with dry eye symptoms, Schirmer and TBUT. Impression cytology could not conclusively differentiate the dry eye status in diabetic patients from controls.

Financial Disclosure:

None