Posters

Treatment of anterior segment perforations with intracameral platelet-rich plasma (PRP) injection

Poster Details

First Author: O.Abdalrahman SPAIN

Co Author(s):    A. Rodríguez   J. Alió                 

Abstract Details

Purpose:

Autologous Platelet-rich plasma (PRP) is a blood derived product without preservatives and rich in proteins, cytokines and growth factors which make it possible for cells to proliferate, and migrate, thus stimulating cell adhesion molecules, tissue regeneration and wound healing. The aim of this study is to evaluate the efficacy of injecting autologous platelet-rich plasma (E-PRP) in the anterior chamber for treating anterior segment perforations.

Setting:

This new therapeutic approach was carried at Vissum Instituto Oftalmologico de Alicante, University Miguel Hernandez, Alicante, Spain.

Methods:

This study consists of two cases with two different pathologies led to anteriorsegment perforation. First case a man with Axenfield-Rieger’s syndrome with leaky bleb post glaucoma filtering surgery with mitomycin C in his only seeing eye. Second case a female with perforated dystrophic cornea following keratopigmentation surgery for her blind and cosmetically deformed eye. Both patients suffered from dramatic decrease of intra-ocular pressure as a result of the anterior segment perforation. The patients were intracameral injected with 0.3 ml of autologous platelet-rich plasma; followed by YAG laser to dissolve the remnants of clotted E-PRP in the anterior chamber.

Results:

Complete healing of the perforations was observed. For the first case he had a well formed diffuse bleb and the second case the corneal perforation was sealed with mild increase of the corneal thickness. Intraocular pressure (IOP) was measured by Goldman’s applanation tonometry during the follow-up periods of at least 6 months, no filtration or hypotony were observed. IOP remains controlled. Both patients did not report any general or local side effects or allergic reactions.

Conclusions:

The outcomes confirmed that Intracameral platelet rich plasma E-PRP injection is a safe, effective alternative way of managing anterior segment perforation with no intra or postoperative complications.

Financial Disclosure:

None