Posters

Comparison of the early clinical outcomes of transepithelial photorefractive keratectomy with and without the application of mitomycin C

Poster Details

First Author: N.Lu CHINA

Co Author(s):    D. Chen   S. Chen   Q. Wang              

Abstract Details

Purpose:

To compare the alternation of postoperative corneal epithelial thickness (ET), the incidence rate of haze and the refractive correction effectiveness (including the safety and efficacy indices) after applying or not applying Mitomycin C (MMC) in Transepithelial Photorefractive Keratectomy (TransPRK) surgery.

Setting:

Refractive Surgery Center, Wenzhou Medical University Affiliated Eye Hospital, China

Methods:

Prospective cohort study. The inclusion criteria were myopic patients under 40 with preoperative spherical equivalents were ≥ -12.00D, best corrected visual acuity ≥ 20/20. A total of 37 patients (65 eyes) consecutive underwent TransPRK surgery, with 17 patients (26 eyes) simultaneously treated with MMC during operation. Corneal ET mapping mode of RTVue spectral-domain optical coherence tomography (Optovue, Inc, Fremont, CA) was used to measure the ET preoperatively and 1st, 3rd month postoperatively. The incidence rate of haze was determined by 2 experienced ophthalmologists and the refractive correction effectiveness was assessed.

Results:

At 1 month postoperatively, compared with the ET before surgery, the alteration of ET in MMC-treated eyes and in MMC-nontreated eyes was statistically different in the central region (P = 0.032), 2-5 mm temporally (P = 0.004), inferiorly-nasally (P = 0.039), inferiorly (P = 0.029), inferiorly-temporally (P = 0.013). There were no differences in the incidence rate of haze between applying or not applying MMC at postoperative 1, 3 month. (P = 0.952, P = 0.396). The safety index was 0.99 ± 0.06 and 1.06 ± 0.11, respectively, with and without applying MMC at postoperative 3rd month (P ＜ 0.05).

Conclusions:

The application of MMC during TransPRK hampered the growth of the central and parts of paracentral regions within 2-5 mm diameter of the corneal ET at postoperative 1 month, but this effect failed to be detected 3 months after surgery. TransPRK with and without MMC treatment generated a similar incidence rate of haze. MMC-treated eyes generated a worse profile of safety index, however, the same profile of the efficacy index was observed at postoperative 3rd month.

Financial Disclosure:

None