Posters

Diagnostic efficacy of RNFL and GCC in optical coherence tomography in glaucoma progression

Poster Details

First Author: S.Tanwar INDIA

Co Author(s):    S. Haldipurkar   V. Shetty                 

Abstract Details

Purpose:

To assess sensitivity and specificity of rate of change (RC) in RNFL & GCC in assessing glaucoma progression

Setting:

Laxmi eye institute,Tertiary eye centre Panvel Maharashtra

Methods:

76 glaucoma eyes diagnosed to have Glaucoma (primary open angle and angle closure glaucoma and secondary glaucoma) or glaucoma suspects qualifying ANDERSON’S CRITERIA in outpatient department were enrolled. Followed up to 1 year with follow up visit - 0, 6, 12 months (3 visits). Patients underwent examinations on both perimetry and optical coherence tomography on each visit. Glaucoma progression analysis (GPA) and RC of RNFL and GCC were assessed and compared.

Results:

76 eyes with mean age of 54.82 years were included. Sensitivity (SN) of RNFL RC was 7.14% (95% confidence intervals [CI]: 0.18% - 33.9%) whereas specificity (SP) was 87.1% (95% CI: 76.1%-94.3%). The negative predictive value (NPV) was 80.6% (95% CI: 69.1-89.2%); however positive predictive value (PPV) was 11.1% (95% CI: 0.28%- 48.2%).  Similarly SN of GCC was 0% (95 CI: 0-23.2 %) and SP was 90.3% (95% CI: 80.1- 96.4%). The NPV was 80% (95% CI: 68.7- 88.6%) however PPV was 0 % (95% CI: 0-45.9%).

Conclusions:

RC of RNFL and GCC showed very poor sensitivity & fair specificity in diagnosing glaucoma progression however longer follow ups are required to assess its utility in glaucoma progression. Limited agreement between structural and functional change in glaucoma progression emphasise importance of assessing both while making clinical decisions.

Financial Disclosure:

None