Posters

Mytomycin C (MMC) toxic effects in anterior chamber after glaucoma surgery

Poster Details

First Author: C.Sánchez Sánchez SPAIN

Co Author(s):    B. Puerto Hernández   C. López Caballero   I. Contreras Martín   M. Lorente Hevia           

Abstract Details

Purpose:

To report two cases of anterior chamber toxicity secondary of mitomycin C (MMC) application in glaucoma surgery.

Setting:

Clínica Rementería.

Methods:

We describe 2 cases of 2 different types of isolated glaucoma surgery, mini Express shunt device (Express) and non penetrating deep sclerectomy (NPDS), associated with 40 seconds of exposure to MMC without complications, that developed MMC anterior chamber toxicity, each with different intensity. Both of them were performed in the last 5 years in our center.

Results:

Case 1:an Express surgery were performed to a phakic 52 myopic man. Three weeks after surgery, started with pigmented tyndall and pigmentation of filtration bleb. Corticosteroids drops were increased and tyndall were resolved. Bleb pigmentation persisted but no progression were observed since 4th month after surgery. Case 2:NPDS were performed in a pseudophakic, 82 myopic woman. Three weeks after surgery started with pigmented tyndall and non-reactive mydriasis associated with bleb pigmentation and uncontrolled intraocular pressure. Even though several medical treatment were tried, a year after surgery she presents non-reactive mydriasis, endothelial pigmentation and two hypotensive drugs to control glaucoma progression.

Conclusions:

We observed two cases of MMC toxicity in non-complicated glaucoma surgery. Both of them started with intraocular signs 3 weeks after surgery with differents impact in long term follow up. Nowadays, we couldn't establish the exact mechanism of intraocular alteration and the best treatment to mitigate the consecuences.

Financial Disclosure:

None