Posters

Evaluation of endothelial cell loss and anterior chamber inflammation following selective laser and its IOP-lowering efficacy

Poster Details

First Author: S.Raj INDIA

Co Author(s):    D. Maurya   F. Thoturthody   S. Kaushik   S. Pandav   C. Malhotra        

Abstract Details

Purpose:

Primary outcome measure was: 1. To evaluate and quantify endothelial cell loss following  SLT 2. To quantify anterior chamber inflammation before and after SLT with laser flaremetery Secondary outcome was IOP reduction following SLT

Setting:

Glaucoma clinic of Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India- a tertiary referral hospital.

Methods:

This was  prospective, non comparative, interventional , observational study  in 33 eyes of 32 diagnosed patients of POAG and OHT , assessed after detailed ocular examination. This study was undertaken for one and a half year between 1st June,2017- 31stNovember, 2018. A minimum follow up of 6 months was done. Patients were followed up on day1,1 week, 1 month, 3 months and 6 months

Results:

: Endothelial cell count decreased from pre SLT level of 2515.206.48 cell/ mm2   to 2492.216+73 cells/ mm2  at 6 Months FU was insignificant  .  Pre and post SLT LFM done on 1 Day, 1 Week and 1 Month. Baseline LFM was 4.885 (SD=0.5997) and post SLT 1 Day was 6.245(SD=0.7175),   statistically significant( p<0.026) only on 1st day .  IOP decreased from 26.18 ± 3.86 mmHg to 19.52 ± 5.65 mmHg at 6 month FU following SLT,  significant at ( P<0.001). At 6M, Complete success was noticed in 75.75% eyes and qualified in 84.84% eyes ( IOP reduction ≥3 mmHg) .

Conclusions:

At the end of 6 month IOP reduction success rate was 50%.  There were no significant changes found in corneal endothelial count and its morphology, which shows minimal energy used during SLT was within safe limit. . Post SLT, no significant inflammation was found, indicating that post SLT, no antiinflammatory medication is required.  There were no significant ocular complications or patient morbidity associated with the procedure.  Thus, SLT can be an effective alternative in lowering IOP in Indian POAG and OHT patients. However larger studies with longer follow up are required for assessing its efficacy in Indian population.

Financial Disclosure:

None