Posters

Our experience of treatment in patients with open-angle glaucoma with a citicoline drug

Poster Details

First Author: Z.Kuryazova UZBEKISTAN

Co Author(s):    N. Yangieva                    

Abstract Details

Purpose:

To evaluate the efficiency of treatment of the patients with open-angle glaucoma with the drug of citicoline.

Setting:

Tashkent State Dental Institute.

Methods:

Citicoline - cytidine-5.Mono hydrochloride diphosphate (2 triethylammonio ethyl ether hydroxide). 28 patients (51 eyes) with primary open-angle glaucoma of stages I-III were treated, average age are 68.7 ± 3.0. Intraocular pressure in all patients was normalized with antihypertensive therapy. The average IOP tonometry was 19.6 + ± 1.2 mm Hg. The maximum IOP level did not exceed 24 mm Hg and standard ophthalmologic examinations were made to all patients: visiometry, biomicroscopy, tonometry, tonography, perimetry. Every days Citicoline was administered to the patients intravenously by 4 ml at a dose of 1000 mg / day for 15 ml of saline.

Results:

Visual acuity before treatment was 0.68– 0.31, after 10 days 0.74–0.27.  The visual fields on 19 eyes were higher compared to the initial ones, in 21 eyes the visual fields were at the level of the original ones and on 11 eyes the state of the visual fields somewhat deteriorated. The number of points with normal sensitivity according to perimetry was increased on average from baseline 76.2 ± 25.0 to 86.7 ± 22.0 (M ± m), the difference is not statistically significant (p≥0.05). The number of absolute livestock decreased from baseline 33.2 ± 12.0 to 26 ± 7.0 (p≥0.05).

Conclusions:

the analysis of the obtained results indicates a fairly high clinical efficacy of the drug of Citicoline in the conservative treatment of patients with open-angle glaucoma with normalized intraocular pressure. The application of the drug allows him to recommend for the expansion of treatment options for primary open-angle glaucoma in outpatient practice.

Financial Disclosure:

None