Posters

Ocular risk factors for progression of open-angle glaucoma

Poster Details

First Author: S.Kostianeva BULGARIA

Co Author(s):    M. Konareva-Kostianeva                    

Abstract Details

Purpose:

To assess the weight of ocular risk factors for progression of open-angle glaucoma (OAG).

Setting:

Medical University Plovdiv, Bulgaria

Methods:

We followed up 70 treated patients with OAG for period of 8 years. Fifty four of them showed progression in one or in both eyes. We analyzed 20 patients with Rate of Progression (RoP) > -1 dB/year, 20 patients with RoP < -1 dB/year and 18 patients with no progression of the disease. The progressive and non-progressive individuals are compared according to the following ocular risk factors: intraocular pressure (IOP) variables (initial IOP, peak IOP, mean IOP and IOP fluctuations), visual field changes before treatment (initial mean deviation – MD), pseudoexfoliations, central corneal thickness (CCT), myopia and undergone IOP-lowering surgery.

Results:

Progressors had more IOP fluctuations during the follow up period than non-progressors: 4.1±1.7 vs 2.8±1.7 (mean±SD), P=0.04. Peak IOP of fast progressors was higher than peak IOP of slower progressors (26±6 mmHg vs 22±7 mmHg, without significance, P=0.09). We observed correlations between peak IOP and RoP (R=-0.282; P=0.032) and between peak and IOP fluctuations (R=-0.829; P<0.001). We found that pseudoexfoliations were not significant predictor for OAG progression (P=0.29). Initial MD and thinner cornea have not been always associated with subsequent progression. Early IOP-lowering surgery was very important factor for stabilization of visual field changes.

Conclusions:

Our results suggest that the long term IOP fluctuations are a significant risk factor for glaucoma progression. The IOP-lowering surgery is a factor for non-progression.

Financial Disclosure:

None