Posters

Evaluation of antihypertensive medications' effect on eye hydrodynamics

Poster Details

First Author: Kh. Abulkasimova UZBEKISTAN

Co Author(s):    M. Karimova                    

Abstract Details

Purpose:

Furthermore, the European Glaucoma Society recommends starting glaucoma treatment with monotherapy as the most preferred long-term treatment option with preservation of life quality (EGS, 2008). The main pathogenetic element determining the course of glaucoma is the change in the eye hydrodynamic processes. The objective of the research is the comparative assessment of antihypertensive medications effect on eye hydrodynamics.

Setting:

The setting was Tashkent Medical Academy, 3rd clinic, Ophthalmology department. It was a masters science research. Tashkent. Uzbekistan.

Methods:

There were 2 groups: control group ‒ 30 patients (60 eyes), used Dorzamed thrice a day; main group ‒ 30 patients (60 eyes) were prescribed Azopt twice a day. According to Nesterov tonography, the surveyed (62.5%) had an increased intraocular fluid (IOF) production; others (15.0%) had a decreased outflow. The combination of the outflow decrease and the IOF production increase occurred in 18 patients (36 eyes ‒ 30.0%). In all cases, there was an ascent in the Becker coefficient. Dynamic and follow-up examinations were performed in 10 days, in 1, 3 and 6 months during the treatment.

Results:

In all groups, there was a twofold decrease in the moisture production, a decrease in the Becker coefficient (KB) by an average of 2 times compared with the initial KB reliably. Crucially, the effect of Dorzamed weakens with prolonged use, which is confirmed by watery component production increase (by 10%) by 6 months of observation, but under the action of Azopt, by the end of the observation period, this coefficient increased on average by almost 2.5 times, and P0 decreased on average by 1.3–1.6 mm Hg. The average value of the lightness coefficient reached 0.48 mm3/min.

Conclusions:

Thus, these drugs in both groups studied normalized hydrodynamic indicators of the eyes of glaucoma patients by reducing moisture production, and ensured a long-term stable normalization of ophthalmotonus pressure in patients.

Financial Disclosure:

None