Posters

Biomechanical comparison between healthy, subclinical keratoconus and keratoconus before or after corneal cross-linking (CXL)

Poster Details

First Author: Q.Zeng CHINA

Co Author(s):    L. Jiang                    

Abstract Details

Purpose:

To compare biomechanical outcomes between healthy, subclinical keratoconus and keratoconus before or after corneal cross-linking (CXL)

Setting:

To overcome the possible weakness of the ORA,  Corvis ST is able tomonitor the re sponse of the cornea to an air puff via  Scheimpflug camera, and uses the acquired images to produce estimates of intraocular pressure (IOP) and dynamic corneal response (DCR) parameters.

Methods:

Eighty-five eyes were studied in three groups: group 1 (n=36) healthy eyes, group 2 (n=28) subclinical keratoconus , group 3 (n=21) keratoconus with CXL . Corneal biomechanical parameters obtained with the Corvis ST (OCULUS Optikgeräte GmbH; Wetzlar, Germany) were assessed in 3 groups and keratoconus eyes 1 year after CXL.

Results:

Most biomechanical parameters between normal eyes, subclinical eyes and keratoconus demonstrated signifcant differences gradually(P < 0.05) , such as hardness and thickness parameters decreased gradually, and shape variable increased gradually.One year after keratoconus cross-linking, some biomechanical parameters developed to normal and subclinical level, HC-DA,HC-deflection amplitude,deflection area and integrated radius were lower than those before surgery(P < 0.05), and SP-A1 increased after CXL(P < 0.05)，but these did not return to subclinical and normal level.

Conclusions:

This study suggests that Corneal Biomechanics is promising to be an effective method for the diagnosis of subclinical keratoconus.Corneal cross-linking can effectively prevent the development of keratoconus and the recovery of Corneal Biomechanics.

Financial Disclosure:

None