Posters

Longitudinal comparison between clinical outcomes of conventional and accelerated collagen cross-linking for progressive keratoconus

Poster Details

First Author: D.Viswanathan AUSTRALIA

Co Author(s):    J. Males                    

Abstract Details

Purpose:

To compare the long-term outcomes of conventional corneal collagen crosslinking (CXL) to accelerated CXL for progressive keratoconus.

Setting:

Envision Eye Centre, Sydney

Methods:

Comparative clinical study of consecutive progressive keratoconic eyes that underwent either conventional CXL (3 mW/cm2 ultraviolet-A light irradiance for 30 minutes) or accelerated CXL (9 mW/cm2 ultraviolet-A light irradiance for 10 minutes). Eyes with minimum 24 months follow up were included. Post-procedure changes in keratometry readings  including maximal keratometry (Kmax), best spectacle corrected visual acuity (BSCVA) and root mean square higher order aberrations (RMS HOA) were analysed.Twenty five eyes had conventional CXL (mean 57.28 ± 23.34 months follow up) and 25 eyes had accelerated CXL (mean 40.64 ± 10.92 months follow up).

Results:

A significant reduction in Kmax by by -1.66 ± 2.05 D (p = 0.0005) was seen after conventional CXL. A reduction in Kmax by  -0.63 ± 2.07 D (p = 0.14) was noted after accelerated CXL . After conventional CXL, an improvement in LogMAR BSCVA by mean -0.07 ±  0.17 (P = 0.06) and a reduction in RMS HOA by mean -0.24 ± 0.72 (P = 0.12) was seen, however the changes were not statistically significant. In comparison, significant  improvements  in LogMAR BSCVA by mean -0.11 ± 0.18 (P = 0.006) and in RMS HOA by mean -0.34 ± 0.61 (P = 0.01) were noted after accelerated CXL.

Conclusions:

Both conventional and accelerated CXL appear to be effective in stabilising progressive keratoconus in the long-term. Although the reduction in corneal curvature was more pronounced after conventional CXL, the visual outcomes were better  after accelerated CXL.

Financial Disclosure:

None