Posters

Long-term topographic, densitometric and clinical outcomes of accelerated collagen cross-linking for progressive keratoconus

Poster Details

First Author: D.Viswanathan AUSTRALIA

Co Author(s):    J. Males                    

Abstract Details

Purpose:

To study the longitudinal topographic, densitometric and clinical outcomes of accelerated corneal collagen crosslinking (CXL) for progressive keratoconus.

Setting:

Envision Eye Centre, Sydney

Methods:

Clinical study of 25 consecutive progressive keratoconic eyes that underwent accelerated CXL (9 mW/cm2 ultraviolet-A light irradiance for 10 minutes). Eyes with minimum 24 months follow up were included. Post-procedure changes including maximal keratometry (Kmax), total corneal densitometry, best spectacle corrected visual acuity (BSCVA) and root mean square higher order aberrations (RMS HOA) were analysed at baseline and follow up visits.

Results:

Twenty five eyes underwent accelerated CXL (mean 40.64 ± 10.92 months follow up, range 24 – 60 months) .  A reduction in Kmax by -0.63 ± 2.07 D (p = 0.14) was noted at final follow up. Total corneal densitometry values increased significantly in the 0.0 to 2.0 mm annulus (p = 0.02), 2.0 to 6.0 mm annulus (p = 0.04) and the total cornea layer (p = 0.04) at final follow up. Significant improvements in LogMAR BSCVA by mean -0.11 ± 0.18 (P = 0.006) and in RMS HOA by mean -0.34 ± 0.61 (p = 0.01) were also noted.

Conclusions:

Accelerated CXL seems to be effective in stabilising progressive keratoconus in the long-term with improvements in corneal curvature and visual acuity and increase in corneal densitometry observed.

Financial Disclosure:

None