Posters

Three-year follow-up of accelerated transepithelial corneal collagen cross-linking for progressive paediatric keratoconus

Poster Details

First Author: M.Tian CHINA

Co Author(s):    W. Jian   X. Zhang   Y. Shen   X. Zhou           

Abstract Details

Purpose:

To investigate the long-term safety and efficacy of accelerated transepithelial corneal cross-linking (ATE-CXL) in children with progressive keratoconus.

Setting:

Single-center clinical institution.

Methods:

Fifty-three eyes of 41 pediatric patients (34 boys and 7 girls) with a mean age of 14.81±1.96 years undergoing ATE-CXL were enrolled in the study. Corrected distance visual acuity (CDVA) and manifest refraction were assessed preoperatively and 36-month postoperatively. Maximum keratometry (Kmax) corneal thickness (CT) and corneal densitometry were measured using Pentacam preoperatively and 1, 6, 12, and 36 months postoperatively. Pachymetry and epithelial thicknesses were measured using optical coherence tomography preoperatively and 6, 12, and 36 months postoperatively.

Results:

There were no complications in any cases during or after ATE-CXL. Thirty-six months postoperatively, CDVA improved from 0.32 ± 0.28 to 0.25 ± 0.25 (P=0.02). No statistically significant differences were present in Kmax or CT during the 36-month follow-up (P>0.05). The densitometry values of the total layer at 0 to 2mm was 15.56 ± 2.20 postoperatively and 15.36 ± 1.86, 14.60 ± 1.56, 14.55 ± 2.49 and 14.66 ± 3.87 at 1, 6, 12, and 36-month postoperatively, which were significantly lower than the preoperative ones (P<0.05). The corneal pachymetry and epithelial thicknesses remained stable during the 36-month follow-up (P>0.05).

Conclusions:

ATE-CXL is a safe and effective treatment in pediatric progressive keratoconus patients. The Kmax and CT values remained stable and the corneal densitometry values decreased significantly during the 36-month follow-up.

Financial Disclosure:

None