Posters

Short and long-term follow-up after conventional vs accelerated corneal collagen cross-linking: comparative study

Poster Details

First Author: R.Shehada JORDAN

Co Author(s):                        

Abstract Details

Purpose:

To compare short and long-term outcomes in patients with progressive keratoconus treated with either conventional or accelerated corneal collagen cross-linking.

Setting:

It was conducted at two main Hospitals  in Palestine. Center A has used the conventional treatment protocol, whereas Center B has used the accelerated treatment protocol.  The study was conducted from January 2014 to December 2018. It was approved by Institutional Review Board.

Methods:

It is a prospective non- randomized cohort study 191 eyes. Of them, 91 eyes were treated with conventional crosslinking (CXL;3mW/cm2 for 30 minutes), and 100 eyes was treated with accelerated crosslinking (aCXL; 30mW/cm2 for 3 minutes). Pre-operative and post-operative visual acuity, manifest refraction and corneal topography were evaluated and compared at different intervals of 3,6,12,24 and 36 months.

Results:

Both groups show significant improvement from baseline at final follow up in terms of uncorrected visual acuity. But the conventional method shows more improvement at final follow up (cCXL; LogMAR 0.22, aCXL; LogMAR 0.54, p=0.03). There was no significant difference in terms of best corrected visual acuity. Both groups show insignificant improvement in spherical equivalent(SE) and cylinder. K1, K2 show comparable improvement in both groups, Kmean and Kmax show insignificant improvement from baseline in both groups. Central corneal thickness shows minimal change from baseline, with significant improvement by cCXL (416.38 μm) over aCXL (462.75 μm) (p=0.028)

Conclusions:

Accelerated and conventional CXL appear to Kmean comparable effectiveness in stabilizing progressive keratoconus in the short and long-term.

Financial Disclosure:

None