Posters

Results of accelerated collagen cross-linking protocols for advanced keratoconus

Poster Details

First Author: T.Rybertt CHILE

Co Author(s):    E. Pimentel   I. Henriquez   R. Moreno   F. Valenzuela           

Abstract Details

Purpose:

To evaluate the effectiveness of two accelerated collagen cross-linking protocols in halting the progression of advanced keratoconus.

Setting:

A single ophthalmology centre in Santiago, Chile.

Methods:

Retrospective analysis of outcomes of accelerated corneal collagen cross-linking (A-CXL) in patients with advanced Keratoconus with steepest keratometry (Kmax) between 58 and 70 diopters (D). Minimum follow-up of 2. Patients with prior ocular surgical procedures (including intracorneal ring segment implantation) were excluded. As previous reported studies, progression was defined as the increase of Kmax ≥ 1.0 D per year.

Results:

We included 28 eyes of 26 patients. The average age was 20 years at the moment of A-CXL and 61% were men. Mean preoperative Kmax was 61.68 (±3.41). Two years after the procedure, mean Kmax was 59.51 (±4.15); and three years after A-CXL the mean Kmax was 59.41 (±1.33). Both represent a significant decrease in the steepest keratometry (p=0.002 and p=0.01). Mean thinnest corneal pachymetry was 430.2m (±28.9); 428.3m (±31.7) and 432.6m (±37.9) previous to surgery, at two and three years of follow-up, respectively. No patient progressed after two or three years of follow-up or required additional treatment.

Conclusions:

Corneal collagen cross-linking is a procedure design to stop progression of Keratoconus. In this retrospective study we demonstrated the effectiveness of accelerated protocols in halting the increment of the steepest keratometry at a two and three year follow-up in patients with advanced Keratoconus (Kmax ≥58 dp).  Further prospective studies are needed to establish the appropriate protocol for this group of patients.

Financial Disclosure:

None