Posters

In vivo examination of the CorNeat KPro: a novel keratoprosthesis

Poster Details

First Author: G.Litvin ISRAEL

Co Author(s):                        

Abstract Details

Purpose:

To evaluate the biocompatibility of the CorNeat KPro, a novel keratoprosthesis, following implantation into the eyes of New Zealand White (NZW) rabbits for a period of 6 months.

Setting:

Envigo labs, Nes Ziona, Israel

Methods:

Eight male NZW rabbits were subjected to a unilateral intraocular implantation of the CorNeat KPro, while the contralateral eye serves as an untreated control. Eight animals are clinically observed for a duration of 6-months to assess safety, during which the eyes are repeatedly monitored by slit-lamp biomicroscopy. At termination, eyes will be enucleated and evaluated histologically.

Results:

To date, clinical evidence shows progressive integration and cessation of inflammatory response. Eyes are all intact with no evident breach of integrity or leak of aqueous humour. Animals exhibit use of implanted eyes routinely. Some animals exhibit iatrogenic cataract.

Conclusions:

The CorNeat KPro device safely integrates into native tissue. Results suggest great potential for its application in a range of human corneal diseases and injuries.

Financial Disclosure:

... gains financially from product or procedure presented, ... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, ... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, ... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented, ... is employed by a for-profit company with an interest in the subject of the presentation, ... has significant investment interest in a company producing, developing or supplying product or procedure presented