Posters

Clinical outcomes and complications of Descemet's membrane endothelial keratoplasty vs Descemet's stripping automated endothelial keratoplasty

Poster Details

First Author: Y.Chen CANADA

Co Author(s):    R. Tan   F. Mostofian   H. Nithianandan   S. Ziai   G. Mintsioulis   K. Baig     

Abstract Details

Purpose:

In this retrospective study, the visual outcomes and postoperative complications after Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) were compared.

Setting:

University of Ottawa Eye Institute, Ottawa, Canada.

Methods:

This was a retrospective chart review of patients who underwent DMEK (159 eyes) and DSAEK (388 eyes) at a Canadian academic hospital from January 2008 to December 2016.   This is a retrospective chart review of consecutive patients who underwent DMEK or DSAEK.  Student t-test was used to compare best corrected visual acuity (BCVA), visual acuity gained compared to baseline and graft survival rate at baseline, 1, 3, 6 months and 2-4 year follow-up.

Results:

Baseline BCVA of patients who underwent DMEK was significantly better compared to those who underwent DSAEK (0.87 vs. 1.3 logMAR, p<0.01).  At one month follow up, vision gained with DSAEK (15.8 letters) was significantly higher compared to DMEK (5.8 letters, p= 0.04).  However, this difference was not observed at all other evaluated time points after (p>0.05).  Early graft failure in the first 3 months was more common in the DSAEK group. The overall graft failure rate is similar in both groups (25% DMEK versus 29% DSAEK, p=0.3).

Conclusions:

No long-term difference was observed between DMEK and DSAEK in visual acuity gained and graft failure rate. Although DSAEK showed higher rates of graft failure in the first three months, overall the rate of graft survival is similar in the long term.

Financial Disclosure:

None