Posters

Serum 25-hydroxyvitamin D, selenium, zinc and copper in patients with keratoconus

Poster Details

First Author: S.Zarei Ghanavati IRAN

Co Author(s):    B. Yahaghi   S. Hassanzadeh   H. Hakimi   P. Eghbali           

Abstract Details

Purpose:

To assess the possible association between keratoconus (KC) and serum levels of 25-hydroxy-vitamin D (25OHD), Selenium (Se), Zinc (Zn), and Copper (Cu) and to compare it with age-matched

Setting:

Khatam eye hospital, Mashhad, Iran.

Methods:

One hundred patients with KC and 100 normal subjects were included. The two groups were compared for serum 25OHD and serum levels of three trace elements: Se, Zn, and Cu. These factors were also compared between groups with different KC stages.

Results:

Serum levels of vitamin D, Zn, Cu, and Se were significantly different between the KC and normal groups (P-value= 0.041, P-value=0.015, P-value=0.004 and P-value=0.038, respectively). 25OHD level was not significantly different between the dufferent stages of KC (p=0.528). KC stage groups were not significantly different for mean serum Zn, Cu, and Se (P=0.130, P=0.98, P=0.113, respectively). There was no significant correlation between KC severity stage and 25OHD serum level (P=0.317). A significant correlation was found between KC stage and Zn level (P=0.023, r=-0.227) and serum Zn was lower in patients with more advanced KC.

Conclusions:

Lower serum 25OHD, Cu, Zn, and Se was found in the KC group compared to the control group. The results of this study suggest that a lower antioxidative activity may be involved in the possible etiology of KC. Future studies are needed to verify the usefulness of 25OHD and these trace elements’ supplementation in the prevention and stopping the progression of KC.

Financial Disclosure:

None