Posters

Paraproteinemic keratopathy associated with lymphoproliferative disease: a case report

Poster Details

First Author: J.Betkova CZECH REPUBLIC

Co Author(s):    P. Skalicka   M. Meliska   T. Stopka   P. Liskova           

Abstract Details

Purpose:

To present a case with chronic lymphoid leukemia and corneal deposition.

Setting:

Case report of a 68 years old male who presented to General University Hospital in Prague with decreased visual acquity due to corneal opacities.

Methods:

Detailed ocular examination was performed as well as systemic evaluation which included bone marrow biopsy. The TGFBI gene were screened by conventional Sanger sequencing to exclude an initial diagnosis of a lattice and/or a granular corneal dystrophy.

Results:

A 68-year-old male patient was referred with a diagnosis of a TGFBI-associated corneal dystrophy. BCVA was decreased to 0.4 in both eyes and remained unchanged for 4.5 years of follow-up visits. Linear branching opacities in deep central stroma were documented in both eyes. No TGFBI mutations were found. Systemic evaluation confirmed chronic lymphoid leukemia with monoclonal IgGκ light chains production detected in blood and urine.

Conclusions:

A diagnosis of paraproteinemic keratopathy should be considered in all individuals with bilateral corneal opacities. Patients need to undergo complex systemic examination to determine the severity of their haematological disease. Even if systemic treatment is not necessary, regular hematologic follow-up is recommended.

Financial Disclosure:

None