Posters

Inhibition of platelet function after ocular administration of non-steroidal anti-inflammatory drugs

Poster Details

First Author: C.Cagini ITALY

Co Author(s):    A. Iannone   L. Amato   A. Mezzasoma   E. Falcinelli   T. Fierro   P. Gresele     

Abstract Details

Purpose:

To assess the comparative effects of two commonly used nonsteroidal anti-inflammatory drugs (NSAID), indomethacin and diclofenac, on circulating blood platelets in patients undergoing cataract surgery

Setting:

Department of Surgical and Biomedical Science, Section of Ophthalmology, University of Perugia, Perugia, Italy

Methods:

20 patients planned to undergo cataract surgery were randomized to the use of an ophthalmic solution containing Diclofenac or Indomethacin. Blood was taken at enrollment (baseline) and after 3 days of therapy (1 drop, 4 times a day). Arachidonic Acid (AA)-induced light transmission aggregometry (LTA), PFA-100® C-EPI, circulating platelet P-Selectin expression by flow cytometry and serum and AA-induced TxB2 production were evaluated before and after eyedrop therapy.

Results:

AA (0.1–0.2 mM)-induced LTA was significantly reduced after ocular indomethacin but not after diclofenac. PFA-100® C-EPI closure time was also significantly prolonged in the indomethacin group but not in the diclofenac group. Circulating platelet P-selectin expression was significantly reduced after treatment with indomethacin compared with diclofenac. Finally, treatment with eyedrop indomethacin, but not with diclofenac, strikingly suppressed AA-induced TxB2 generation, while treatment with diclofenac did not modify it.

Conclusions:

Our data show that indomethacin administered by ophthalmic eye drops has a relevant systemic antiplatelet effect. This should be taken into account in patients under concurrent therapy with antiplatelet or anticoagulant agents.

Financial Disclosure:

None