Posters

Analysis of the deterioration of acrylic intraocular lenses

Poster Details

First Author: K.Kawai JAPAN

Co Author(s):                        

Abstract Details

Purpose:

Acrylic intraocular lenses (IOLs) are manufactured by cast molding and lathe-cutting. Due to severe accelerated deterioration, the appearance, weight, and light transmittance of IOLs manufactured by cast molding are markedly impaired, as reported in the 33th Congress of the ESCRS. In our study, the structural changes of IOLs and leaked components of a preservative solution were analyzed to compare the degree of deterioration.

Setting:

Tokai University School of Medicine.

Methods:

For accelerated deterioration, the IOLs were placed in a screw-top bottle filled with ultrapure water at 100°C for 115 days (equivalent to 20 years, assuming that 23 days in an oven at 100°C corresponds to 4 years at 37°C). The structural changes of IOLs and leaked components of the preservative solution were analyzed by total reflection infrared spectroscopy and gas chromatograph mass spectrometry, respectively. Tested IOLs: Cast molding: hydrophobic colored lens SN60WF, XY1 , and AN6K; Lathe-cutting: hydrophobic colored lens ZCB00V , YA-60BBR, NS-60YG , and hybrid colored lens NX-60.

Results:

Structural changes: Peak shifts were noted for SN60WF and AN6K before and after acceleration. Preservative solution components: The peak of phenylethyl alcohol was detected at 4.7 min for SN60WF and XY1, while that of 2-phenoxyethanol was noted at 5.4 min for AN6K.

Conclusions:

The structures of SN60WF and AN6K are easily changed during cast molding. Analysis of the leaked components of preservative solution revealed alcohol leakage only with cast molding. IOLs are easily hydrolyzed during cast molding, resulting in accelerated deterioration.

Financial Disclosure:

None