Posters

Cataract surgery: the effects on the cornea and the ocular surface of intracameral mydriatic and anaesthetic combination vs topical eye drops

Poster Details

First Author: M.Cennamo ITALY

Co Author(s):    E. Favuzza   G. Scali   R. Mencucci              

Abstract Details

Purpose:

To compare postoperative corneal changes and the effects on the ocular surface between the intracameral Mydrane (tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%) and standard mydriatic-anaesthetic eye-drop protocol used during cataract surgery.

Setting:

Careggi Eye Clinic, University of Florence, Italy.

Methods:

This prospective study included 60 patients undergoing phacoemulsification: 30 eyes received Mydrane (Mydrane group) and 30 eyes the standard protocol(oxybuprocain 0.4%+tetracaine 0.1%, phenylephrine10% and tropicamide1%, Standard group). In all eyes pupil diameter was measured during surgery.The effects on the ocular surface were analyzed:Tear Breakup Time(BUT),Schirmer test I(STI) and variations in the Optical Scattering Index (OSI and OSI SD) measured by Optical Quality Analyzing System (OQAS).Ocular Surface Disease Index (OSDI) was evaluated.Confocal Microscopy (IVCM) was used to measure the density of the corneal basal epithelial cells (BEC),sub-basal nerve fibers (NFD).The assessments were examined at baseline, 5 and 15 days after surgery.

Results:

In Mydrane group, the BEC density returned to baseline level at 15 days after surgery with a significantly difference between groups. Better NFD values were found in Mydrane group compared to standard protocol at all follow-ups without statistically significance difference. At all assessments in both groups, ST-I and TBUT decreased significantly compared to baseline, with higher TBUT values in Mydrane than in the Standard group. OSDI score, OSI and OSI SD values improved significantly at 15 days only in the Mydrane group

Conclusions:

Intracameral mydriatic can be considered an effective method to obtain a stable pupil dilation during cataract surgery, with a less damage on corneal epithelial cells and sub-basal nerve fibers. Moreover a less drop cataract surgery showed a better tear film stability  with a good quality vision and a better postoperative patient satisfaction.

Financial Disclosure:

... receives non-monetary benefits from a company producing, developing or supplying the product or procedure presented