Simulated visual acuity performance of monofocal and extended-depth-of-focus intraocular lenses

Session Details

Session Title: Presented Poster Session: Enlarged Depth of Focus vs Multifocal IOLs

Venue: Poster Village: Pod 1

First Author: : J.Schwiegerling USA

Co Author(s): :    J. Lemp-Hull   S. Lane   K. Baker                 

Abstract Details

Purpose:

Predicting clinical performance differences among IOLs is difficult due to varying  clinic study testing conditions across published trials.  By simulating the clinical testing conditions in a raytrace model, the predicted visual performance can be more directly compared between various IOL designs.

Setting:

Bench testing and simulations by Alcon Research LLC, Fort Worth and independent analyses by University of Arizona

Methods:

Custom optical eye models are created based on surface bench measurements for extended depth of focus (EDF) and monofocal IOL designs.  Simulated defocus curves are created by placing an appropriate trial lens (defocus range +1.5D to -2.5D) in front of each custom IOL eye model and raytracing the system to observe the effects of defocus on visual performance.  At each defocus level, simulated optical performance measures (e.g., area under MTF curve) are generated and converted into clinical visual acuity (VA) estimates by applying a calibration function.  Simulated retinal VA chart images are used to visually compare IOLs.

Results:

A comparison of simulated defocus curve against available clinical defocus curve demonstrates the accuracy and validity of the modeling and simulations.  Simulated defocus curves for monofocal an EDF IOLs show differentiation among the two design forms.  Simulated photopic and mesopic, high contrast and low contrast VA chart images at distance, intermediate, and near defocus levels visually differentiate IOL designs.

Conclusions:

While well designed clinical trial data remains the gold standard for understanding visual performance, this validated modeling approach allows for good prediction of IOL clinical performance. Such models provide confidence in the design stage of IOL development, rapid evaluation of different design options and may ultimately lead to improved performance for IOL recipients.

Financial Disclosure:

... is employed by a for-profit company with an interest in the subject of the presentation, ... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented