Efficacy of cyclosporine 0.05% on tear lipid layer and Meibomian gland after cataract operation

Session Details

Session Title: Presented Poster Session: Medical Cornea

Venue: Poster Village: Pod 3

First Author: : J.Shin SOUTH KOREA

Co Author(s): :    J. Lee   J. Kwon   C. Lee   S. Lee              

Abstract Details

Purpose:

To assess the effect of cyclosporine-A (CsA) 0.05% ophthalmic emulsion on lipid layer and meibomian gland after cataract operation

Setting:

prospective, randomized, and double masked clinical trial

Methods:

Prospective, randomized, and double masked clinical trial enrolled 30 eyes with topical CsA and 30 eyes without CsA following cataract surgery. Subjective and objective assessments were performed preoperatively, and over 3 months after operation. Ocular Surface Disease Index (OSDI), tear breakup time (TRUT), shirmer test, and meibomian gland expression and lipid layer thickness (LLT) using Lipiview interferometer were performed.

Results:

At the 3-month evaluation, mean OSDI, BUT, shirmer test showed significantly greater improvement in the eyes with CsA than those without CsA (P < 0.05, respectively). Through lipiview interferometer, average LLT in the eyes receiving CsA showed significantly thicker than that in control eyes (P < 0.05).

Conclusions:

Topical CsA 0.05% twice daily after cataract operation may be effective in the management of meibomian gland and lipid layer following cataract surgery.

Financial Disclosure:

None