Comparison of three presbyopia-correcting intraocular lenses based on the statistical analysis of their performance scores obtained with a mathematical model of their defocus curves

Session Details

Session Title: Multifocal IOLs II

Session Date/Time: Monday 16/09/2019 | 08:30-10:30

Paper Time: 10:20

Venue: Free Paper Forum: Podium 1

First Author: : T.Amzallag FRANCE

Co Author(s): :    P. Rozot   J. Pynson   N. Arbousoff   C. Josse                    

Abstract Details

Purpose:

To evaluate the statistical relevance of a dedicated computer program by comparing the performance scores of three intraocular lenses (IOL): an extended depth of focus IOL (EDOF) (1), a sector-shaped refractive IOL (2) and a diffractive trifocal IOL (3). The IOLs performance scores are obtained through the calculation of the area above their respective defocus curves.

Setting:

OPHTHALMIC INSTITUTE OF SOMAIN

Methods:

Prospective monocentric study on 156 consecutive patients (63.2% females; median age 67). Each monocular corrected defocus curve was entered into a computer program developed to calculate a score proportional to the area between the defocus curve and the 0 LogMAR threshold. Analyses were performed on 156 independent eyes and 229 partially correlated eyes. The scores were analyzed for distant (defocus 0.5 to -0.5D), intermediate (-1.25 to -2.5D), near vision (-2.5 to -3D) and the whole curves, using parametric (ANOVA analysis of variance, taking into account the calculated intra-patient correlation when applicable) and non-parametric (Kruskall-Wallis) two-sided tests at a 5% level.

Results:

In first operated eyes, significant differences were observed between: • The three IOLs at near (p<0.001), distant (p=0.047) and all distances (p=0.041) vision. • (1) and (2) for near (p<0.001), distant (p=0.033) and all distances (p=0.020) vision • (1) and (3) for near (p>0.001), intermediate (p=0.030) and all distances (0.015) vision. Analyses of all operated eyes confirmed these results and found additional significant differences between: • The three IOLs at intermediate vision (p<0.001). • (1) and (2) for intermediate (p=0.002) and all distances (p<0.001) vision • (2) and (3) for intermediate vision (p=0.014) Age (p=0.87) or gender (p=0.48) did not influence the results in multivariate analyses.

Conclusions:

The proposed mathematical model enables the quantitative analysis of presbyopia-correcting IOL performance, by the calculation of scores reflecting the areas over defocus curves. In this study, the statistical analyses allow to find significant differences among the different tested IOLs.

Financial Disclosure:

is employed by a for profit company with an interest in the subject of the presentation