Densitometric and biomechanical corneal characteristics in patients with primary congenital glaucoma

Session Details

Session Title: Corneal Biomechanics

Session Date/Time: Sunday 15/09/2019 | 16:30-18:00

Paper Time: 17:42

Venue: Free Paper Forum: Podium 4

First Author: : B.Benito SPAIN

Co Author(s): :    L. Morales-Fernández   J. García-Bella   L. Perucho-González   J. Martínez-de-la-Casa   J. García-Feijoo                 

Abstract Details

Purpose:

To evaluate the differences in densitometry and corneal biomechanics between healthy subjects and primary congenital glaucoma (PCG) patients. To analyse the correlation between the densitometric and biomechanical variables as well as their glaucoma diagnostic capacity.

Setting:

Cross-sectional study with matched control group.

Methods:

50 eyes of 50 patients with CPG and 40 eyes of 40 healthy subjects were analyzed. The intraocular pressure (IOP) and visual acuity (VA) were collected. Corneal densitometry data by Pentacam topographer (Oculus) was analyzed. Data on corneal hysteresis (CH) and corneal resistance factor (CRF) were obtained using the Ocular Response Analyzer (Reichert). The variables of both groups were compared (T-student), the correlation between variables (Pearson) was calculated and their glaucoma discriminative capacity (area under ROC curve - AUC ROC) was determined.

Results:

Statistically significant differences were detected in densitometric (higher in cases) and biomechanical (lower in cases) variables between both groups (p <0.001). A significant correlation (p = 0.028) was detected between the total densitometry and CH (-0.321) in the cases. AUC ROC of total densitometry and corneal histeresis had the highest values.

Conclusions:

Patients with childhood glaucoma have a higher corneal density in all layers with lower values for corneal hysteresis parameters. The corneal density correlates significantly negatively with the CH in the cases. The corneal density offers a greater AUC ROC than the rest of the parameters (including the IOP). Therefore, it could be concluded that both densitometry and corneal hysteresis could be useful tools in the diagnosis of primary congenital glaucoma.

Financial Disclosure:

None