Comparative analysis of clinical aspects and treatment outcomes between Stenotrophomonas maltophilia and Pseudomonas aeruginosa keratitis

Session Details

Session Title: Ocular Infections & Other Topics

Session Date/Time: Sunday 15/09/2019 | 08:00-10:00

Paper Time: 08:12

Venue: Free Paper Forum: Podium 4

First Author: : C.Cho SOUTH KOREA

Co Author(s): :    S. Lee                             

Abstract Details

Purpose:

Stenotrophomonas maltophilia (SM), gram-negative organism, is a relatively rare causative organism of infections keratitis and is known to have similar bacteriological characteristics to Pseudomonas aeruginosa (PA). The aim of this study is to compare epidemiology, predisposing factor, clinical characteristics and treatment outcomes in patients with SM and PA keratitis at a tertiary referral center in South Korea.

Setting:

Retrospective, case-control study. All of study cases were taken by Department of Ophthalmology, Yeungnam University College of Medicine, South Korea.

Methods:

Fifty-five cases of inpatients with culture-proven SM (21 cases) and PA (34 cases) keratitis were reviewed retrospectively between January 1998 and December 2017. We excluded cases of polymicrobial infection. Epidemiology, predisposing factors, clinical characteristics, and treatment outcomes were compared between the SM and PA groups. Poor clinical outcome was defined as final BCVA worse than 6/60, decrease in visual acuity during treatment, presence of complications, or requiring surgical intervention.

Results:

The mean age was not different between the two groups (54.2:45.1 years, p=0.170). The mean symptom duration was significantly longer in SM (10.4:4.1 days, p=0.009). The m/c predisposing factor was corneal trauma (47.6%) in SM and was contact lens wear (38.2%) in PA. The prior use of topical steroids was more prevalent in PA (4.8:23.5%, p=0.131). There were no differences in mean epithelial defect size (12.7:12.5mm2) and hypopyon (33.3:41.2%) between the two groups. In the treatment outcome, final BCVA <0.1 (20:30.3%, p=0.410), surgical treatment (4.8:11.8%, p=0.639), and poor clinical outcome (26.3:33.3%, p=0.604) were not significantly different between the two groups.

Conclusions:

The SM group was more closely associated with longer symptom duration and corneal trauma, whereas the PA group was more closely associated with younger age, contact lens wear, and prior use of topical steroids. Clinical significance of SM keratitis should be emphasized because the clinical characteristics and clinical outcomes of SM keratitis were not significantly different from PA keratitis.

Financial Disclosure:

None